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Pomegranate: Purple coloured energy bomb.

Updated: Jun 21, 2023

Pomegranate, a hope against prostate cancer

What is the prostate?

Pomegranate juice is known for its many vitality-enhancing properties, including its positive effects on the prostate. Several scientific studies have been conducted to evaluate the effects of pomegranate juice consumption on prostate-related problems and the results are promising.

The prostate is a gland located below the bladder. It plays an important role in the production of seminal fluid, which is essential for male fertility. However, over time, the prostate can be affected by various health problems, such as benign prostatic hyperplasia (BPH) and prostate cancer.

What is prostate cancer?

Did you know that prostate cancer is the second most common cancer in men, after lung cancer? However, within the next ten years, the trend will be reversed [1].

It is a slowly progressing disease, hence the interest in detecting it as early as possible, from the age of 45 in men. It results from the uncontrolled multiplication of prostate cells. The tumour can spread to other parts of the body over a period of several years, such as the lymph nodes near the prostate, the bones or the liver [1]. There may be no symptoms at the beginning of prostate cancer. They start to appear as the prostate increases in size and the urethra is compressed. Prostate cancer can be diagnosed by a digital rectal examination and a blood test for PSA. PSA is the specific antigen of the prostate but not of prostate cancer. Its level can give indications of a potential problem with the prostate. In the event of an attack, PSA is released into the bloodstream in proportion to the severity of the attack. A normal PSA level is 4 ng/mL but a higher level does not necessarily mean cancer [2].

 Our range of pure pomegranate juice
Taking care of your prostate with pomegranate juice

How to take good care of your prostate?

There are several risk factors such as age, heredity, environment and diet. Indeed, studies have shown that diets high in saturated fat and excessive calcium consumption have a negative effect on prostate cancer [3]. However, diet can reduce the risk of developing prostate cancer. An excellent example is the consumption of antioxidants. Indeed, studies have shown that consumption of certain antioxidants reduces the risk of developing prostate cancer. For example, in a study conducted in Finland, a group of individuals receiving vitamin E at a dose of 50 mg/day had a significant reduction in the incidence of prostate cancer [4]. These studies support the idea that the role of antioxidants is crucial in chronic inflammation of the prostate.

In addition, pomegranate juice is rich in antioxidants and polyphenols, which have been associated with a reduced risk of cancer and improved overall health. In particular, the polyphenols in pomegranate juice have been associated with anti-inflammatory, anti-tumour and antioxidant effects. The dominant polyphenols in pomegranate are ellagitannins, such as punicalagin, and phenolic acids, such as ellagic and gallic acids. Punicalagin is considered to be specific to pomegranate. Anthocyanins and quercetin are also found.

The most dramatic study was carried out by Allan Pantuck's team who, by giving 240ml of pomegranate juice daily to prostate cancer patients, saw a significant increase in the time to double PSA levels from 15 to 54 months, a marker of slower tumour growth and longer survival. In addition, patients who continued to take pomegranate juice did not develop metastases during the subsequent 33 months. [5]

Several teams have highlighted the mechanisms by which pomegranate polyphenols have cotherapeutic effects in cancer. They block NF kappa B, an inflammation conductor that is essential for cell proliferation [6]. They interfere with the androgen receptors that act as promoters. They interfere with IGF1, a second messenger of growth hormone that is also a promoter. They block iron and copper, pro-inflammatory minerals with proliferative effects.[7]

Man doing yoga
Pomegranate: good for the prostate

In another study, researchers used pomegranate compounds, such as their polyphenols or pomegranate seed oil, to treat human prostate tumour cells. The pomegranate compounds were able to reduce cell proliferation and induce cell cycle arrest at checkpoints and apoptosis [8]. Apoptosis is a defence mechanism of the body, including the elimination of tumour cells.

Other studies on cell lines prove the anti-cancer effect of certain pomegranate compounds, notably punicic acid or omega 5 [9].

Another study indicates that ellagic acid, a polyphenol contained in pomegranate juice, is a potential chemotherapeutic agent against prostate cancer [10]. In terms of PSA levels, an in vivo study in men with prostate cancer found that consumption of pomegranate juice significantly reduced PSA levels [11].

In addition, another study conducted in 2008 showed that consumption of pomegranate juice slowed the progression of prostate cancer in mice with the disease [11]. This clinical study found that consumption of pomegranate juice significantly inhibited the growth of prostate cancer cells in patients with early-stage prostate cancer. The researchers found that pomegranate juice reduced the growth of prostate cancer cells by 30% to 50%, suggesting that pomegranate juice may be beneficial in the prevention and treatment of prostate cancer.

In conclusion, several clinical studies suggest that drinking pomegranate juice may help prevent certain prostate-related diseases due to its antioxidant content and anti-inflammatory properties. However, it is important to note that these studies were conducted on relatively small samples and further research is needed to confirm these results.


While pomegranate juice offers many benefits for prostate health, it is important to note that it can also interact with certain medications. If you are taking medication for blood pressure or erectile dysfunction, it is important to consult your doctor before consuming pomegranate juice.

In no case can the information and advice offered by Granaline replace a consultation or a diagnosis made by a doctor or a health professional, the only ones able to adequately assess your state of health.

References :

1 Ahissou D, Houndjo G, Akpovi C, Tchogou P, Segbo J. Intérêt du dosage de l’Antigène Spécifique Prostatique (PSA) dans le dépistage du cancer de la prostate chez les patients reçus à la clinique Dr Pierre BONI d’AKPAKPA; 2022

2 Boissier R. L’antigène spécifique de la prostate ou PSA, Progrès en Urologie, 2011

3 Gann PH, Facteurs de risque du cancer de la prostate, 2002

4 Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. 1994 Apr 14;330(15):1029-35. doi: 10.1056/NEJM199404143301501. PMID: 8127329.

5 Allan J Pantuck et al. , Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer, Clinical Trial Clin Cancer Res. 2006

6 Wilkinson JD, Williamson EM. Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis. J Dermatol Sci. 2007 Feb;45(2):87-92. doi: 10.1016/j.jdermsci.2006.10.009. Epub 2006 Dec 6. PMID: 17157480.

7 Galipienzo J, Lablanca MS, Zannin I, Rosado R, Zarza B, Olarra J. Amnesia global transitoria en el contexto de una anestesia general [Transient global amnesia after general anaesthesia]. Rev Esp Anestesiol Reanim. 2012 Jun-Jul;59(6):335-8. Spanish. doi: 10.1016/j.redar.2012.03.015. Epub 2012 May 8. PMID: 22575776 8 Albrecht M, Jiang W, Kumi-Diaka J, Lansky EP, Gommersall LM, Patel A, Mansel RE, Neeman I, Geldof AA, Campbell MJ. Les extraits de grenade suppriment puissamment la prolifération, la croissance des xénogreffes et l’invasion des cellules cancéreuses de la prostate humaine. 2004

9 Jihane Gasmi, Prévention du cancer de la prostate par les composés naturels, 2012

10 Naiki-Ito A, Chewonarin T, Tang M, Pitchakarn P, Kuno T, Ogawa K, Asamoto M, Shirai T, Takahashi S. L’acide ellagique, un composant du jus de fruit de grenade, supprime la cancérogenèse de la prostate androgéno-dépendante par induction de l’apoptose. 2015

11 MB Rettig, D Heber, J An, NP Seeram, JY Rao, H Liu, T Klatte, A Belldegrun, A Moro, SM Henning, et al. Pomegranate extract inhibits androgenindependent prostate cancer growth through a nuclear factor-κβ-dependent mechanism. Mol Cancer Ther. 2008

Mehta, S. R., Yusuf, S., Diaz, R., Zhu, J., Pais, P., Xavier, D., Paolasso, E., Ahmed, R., Xie, C., Kazmi, K., Tai, J., Orlandini, A., Pogue, J., & Liu, L. (2008). Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: the CREATE-ECLA randomized controlled trial. JAMA, 299(21), 2389-2395.

Juan Antonio Giménez-Bastida, María Ángeles Ávila-Gálvez, Juan Carlos Espín, Antonio González-Sarrías (2021) Evidence for health properties of pomegranate juices and extracts beyond nutrition: A critical systematic review of human studies

Allan J Pantuck et al. , Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer, Clinical Trial Clin Cancer Res. 2006

Stavridi, EM Karapanagiotou, KN Syrigos Targeted therapeutic approaches for hormone-refractory prostate cancer Cancer Treat Rev, 36 (2010), pp. 122-130

DS Coffey, KJ Pienta New concepts in studying the control of normal and cancer growth of the prostate Prog Clin Biol Res (1987), pp. 1-73

CP Chuu, JM Kokontis, RA Hiipakka, J Fukuchi, HP Lin, CY Lin, C Huo, LC Su Androgens as therapy for androgen receptor-positive castration resistant prostate cancer J Biomed Sci, 18 (2011), p. 63

DP Petrylak Chemotherapy for advanced hormone refractory prostate cancer Urology, 54 (1999), pp. 30-35

AL Harzstark, EJ Small Castrate-resistant prostate cancer: therapeutic strategies Expert Opin Pharmacother, 11 (2010), pp. 937-945

CS Higano, EJ Small, P Schellhammer, U Yasothan, S Gubernick, P Kirkpatrick, PW Kantoff Sipuleucel-T Nat Rev Drug Discov, 9 (2010), pp. 513-514

S Shah, CJ Ryan Abiraterone acetate CYP17 inhibitor oncolytic Drugs Fut, 34 (2009), pp. 873-880

HI Scher, TM Beer, CS Higano, A Anand, M-E Taplin, E Efstathiou, D Rathkopf, J Shelkey, EY Yu, J Alumkal, et al. Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study Lancet, 375 (2010), pp. 1437-1446

D Schrijvers, P Van Erps, J Cortvriend Castration-refractory prostate cancer: new drugs in the pipeline Adv Ther, 27 (2010), pp. 285-296

FM Yakes, J Chen, J Tan, K Yamaguchi, Y Shi, P Yu, F Qian, F Chu, F Bentzien, B Cancilla, et al. Cabozantinib (XL184), a novel MET and VEGFR2 inhibitor, simultaneously suppresses metastasis, angiogenesis, and tumor growth Mol Cancer Ther, 10 (2011), pp. 2298-2308

DC Smith, MR Smith, EJ Small, C Sweeney, R Kurzrock, MS Gordon, NJ Vogelzang, C Scheffold, MD Ballinger, M Hussain Phase II study of XL184 in a cohort of patients (pts) with castration-resistant prostate cancer (CRPC) and measurable soft tissue disease J Clin Oncol, 29 (suppl 7) (2011) Abstract 127

M Albrecht, W Jiang, J Kumi-Diaka, EP Lansky, LM Gommersall, A Patel, RE Mansel, I Neeman, AA Geldof, MJ Campbell Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells J Med Food, 7 (2004), pp. 274-283

DN Syed, Y Suh, F Afaq, H Mukhtar Dietary agents for chemoprevention of prostate cancer Cancer Lett, 265 (2008), pp. 167-176

AJ Pantuck, JT Leppert, N Zomorodian, N Seeram, D Seiler, H Liker, H-J Wang, R Elashoff, D Heber, AS Belldegrun Phase II study of pomegranate juice for men with rising PSA following surgery or radiation for prostate cancer J Urol, 173 (2005), pp. 225-226

A Malik, F Afaq, S Sarfaraz, VM Adhami, DN Syed, H Mukhtar Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer Proc Natl Acad Sci USA, 102 (2005), pp. 14813-14818

EP Lansky, W Jiang, H Mo, L Bravo, P Froom, W Yu, NM Harris, I Neeman, MJ Campbell Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions Invest New Drugs, 23 (2005), pp. 11-20

L Wang, A Alcon, H Yuan, J Ho, QJ Li, M Martins-Green Cellular and molecular mechanisms of pomegranate juice-induced anti-metastatic effect on prostate cancer cells Integr Biol (Camb), 3 (2011), pp. 742-754

ND Kim, R Mehta, W Yu, I Neeman, T Livney, A Amichay, D Poirier, P Nicholls, A Kirby, W Jiang, et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer Breast Cancer Res Treat, 71 (2002), pp. 203-217

DN Syed, F Afaq, H Mukhtar Pomegranate derived products for cancer chemoprevention Semin Cancer Biol, 17 (2007), pp. 377-385

VM Adhami, N Khan, H Mukhtar Cancer chemoprevention by pomegranate: laboratory and clinical evidence Nutr Cancer, 61 (2009), pp. 811-815

MI Gil, FA Tomas-Barberan, B Hess-Pierce, DM Holcroft, AA Kader Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing J Agric Food Chem, 48 (2000), pp. 4581-4589

C El Kar, A Ferchichi, F Attia, J Bouajila Pomegranate (Punica granatum) juices: chemical composition, micronutrient cations, and antioxidant capacity J Food Sci (2011), pp. C795-C800

Q Zhou, B Yan, X Hu, XB Li, J Zhang, J Fang Luteolin inhibits invasion of prostate cancer PC3 cells through E-cadherin Mol Cancer Ther, 8 (2009), pp. 1684-1691

ME Grossmann, NK Mizuno, T Schuster, MP Cleary Punicic acid is an ω-5 fatty acid capable of inhibiting breast cancer proliferation Int J Oncol, 36 (2010), pp. 421-426

J Gasmi, JT Sanderson Growth inhibitory, antiandrogenic, and proapoptotic effects of punicic acid in LNCaP human prostate cancer cells J Agric Food Chem, 58 (2010), pp. 12149-12156

Tostes, R. C., Carneiro, F. S., & Lee, A. J. (2019). Vascular oxidative stress in hypertension: sowing the seeds of vascular damage. Journal of the American Heart Association, 8(14), e012141.

Sánchez-Villegas, A., Martínez-González, M. A., Estruch, R., Salas-Salvadó, J., Corella, D., Covas, M. I., Arós, F., Romaguera, D., Gómez-Gracia, E., Lapetra, J., Pintó, X., Martínez, J. A., Lamuela-Raventós, R. M., Ros, E., & Gea, A. (2013). Mediterranean dietary pattern and depression: the PREDIMED randomized trial. BMC Medicine, 11(1), 208.

Morris, M. C., Evans, D. A., Tangney, C. C., Bienias, J. L., & Wilson, R. S. (2006). Associations of vegetable and fruit consumption with age-related cognitive change. Neurology, 67(8), 1370-1376.

Astrup, A., Dyerberg, J., Elwood, P., Hermansen, K., & Hu, F. B. (2011). The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? The American Journal of Clinical Nutrition, 93(4), 684-688.


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