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Polyphenols, a secret weapon in the fight against prostate cancer and its swelling?

Updated: Apr 24

Prostate cancer, one of the most widespread cancers in the world, is emerging as a silent threat, affecting a growing number of men throughout the world. Faced with this reality, research is working hard to find preventive solutions. In this quest, polyphenols stand out as valuable natural compounds, thanks to their antioxidant and anti-inflammatory properties. In this article, we explore the underlying mechanisms of prostate cancer and swelling, the potential impact of polyphenols in its prevention and treatment, and the essential tests for assessing prostate health.





What causes prostate swelling and cancer?

The prostate is a gland that forms part of the male reproductive system. It is located below the bladder and surrounds the urethra, which carries urine from the bladder to the outside. This position explains the urinary problems associated with the prostate.

In young men, the prostate is the size of a plum, but as we get older, this organ can swell and cause discomfort.

Pensez au dépistage du cancer de la prostate
Think about prostate cancer screening

Prostate cancer is widespread among men, accounting for 7.3% of all cancer cases worldwide [1], making it a major public health issue.









Several factors are linked to an increased risk of prostate cancer. Age is a key factor, with the risk increasing significantly after the age of 50. In addition, a family history of prostate cancer can increase the likelihood of developing the disease. Lifestyle also plays a crucial role, with obesity, smoking and lack of physical activity associated with a higher risk of developing this form of cancer. Understanding these risk factors is essential for effective prevention and proactive management of prostate health.



Polyphenols to fight cancer?

Studies [2] show that a diet rich in polyphenols could reduce the risk of developing cancer. The polyphenols in pomegranates have protective properties:

  • They attack the communication pathways that control the growth of cancer cells, depriving them of their ability to proliferate[3].

  • They are also capable of increasing the rate of apoptosis in tumour cells [4]. Apoptosis is a natural mechanism by which cells self-destruct when they are damaged or threaten the body, thus helping to defend against cancer and infection.

  • They also block inflammatory processes. [3] a phenomenon that reduces tumour inflammation.

  • Finally, they protect the cell against free radicals through their antioxidant effect. [5] Free radicals result from a chemical reaction called oxidation, which allows cells to "breathe".


What tests can be used to check the health of the prostate?

If symptoms occur, the GP or urologist may examine the prostate by palpating it through the rectum, which is the part of the intestine just behind the anus. The aim of this palpation is to determine whether the prostate has any abnormalities such as an abnormally hard consistency, an increased size compared with normal or the presence of nodules, which are small bumps. [6]

A key marker in monitoring the progress of prostate cancer is the PSA (Prostate Specific Antigen) assay, which monitors prostate activity. Its measurement in the blood is an important factor in the early diagnosis of prostate cancer and in monitoring the progress of the disease.

In a study [7] of patients undergoing active surveillance for prostate cancer, two groups were established: one receiving pomegranate polyphenol supplementation, the other a placebo. Patients receiving the polyphenol supplement showed a slight reduction in PSA levels, while the placebo group showed an increase of around 47%.

These results highlight the benefits of polyphenol supplementation from foods concentrated in these compounds on the progression of prostate cancer.


Rich in antioxidants and polyphenols, pomegranates are highly beneficial to our health and well-being. That's why we've chosen this fruit as the mainstay of our business, because of its vitality-enhancing properties.


At Granaline, you'll find a pure ORGANIC functional juice that contains a certain amount of antioxidants. For example, our pure juice contains vitamin C and vitamin E, which help to reduce oxidative stress (a). What's more, our pure pomegranate juice contains high levels of total polyphenols, is 100% fruit, has no added sugar and no preservatives. An antioxidant bomb!



We've also developed a new product:

Granaline ORGANIC pomegranate concentrate. While we recommend a 240ml glass of Granaline ORGANIC pomegranate juice, you can make do with one or two tablespoons of concentrate to get the antioxidant and total polyphenol content you need. Take care of yourself and your vitality!






References:

[1] World Health Organization; https://www.who.int/fr/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services

[2] Rahul K. Lall; https://www.mdpi.com/1422-0067/16/2/3350

[3] Malik et al, 2005 ; https://www.pnas.org/doi/full/10.1073/pnas.0505870102

[4] Seeram et al, 2005; https://www.sciencedirect.com/science/article/pii/S0955286305000197

[5] Rosenblat et al. 2006; https://doi.org/10.1016/j.atherosclerosis.2005.09.006

[7] Lei Wang et al, 2014 https://doi.org/10.3390/ijms150914949

[8] Molecular mechanisms and bioavailability of polyphenols in prostate cancer. Teodora Costea. Int. J. Mol. Sci. 2019, 20, 1062; doi:10.3390/ijms20051062


(a): EFSA entry no.: Vit C: 129, 138, 143, 148, 3331; Vit E: 160, 162, 1947

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